Depo-Provera Brain Tumor Lawsuit
If you were diagnosed with a meningioma brain tumor after receiving Depo-Provera injections for one year or longer, you may be entitled to compensation. Thousands of women are filing lawsuits against Pfizer for failing to warn about the increased risk of brain tumors linked to prolonged use of this birth control shot. Contact us now for a free, confidential case evaluation.
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Were You Diagnosed With a Meningioma After Using Depo-Provera?
Depo-Provera is an injectable birth control shot manufactured by Pfizer, containing a synthetic hormone called medroxyprogesterone acetate (MPA). Administered every three months, it has been one of the most widely used contraceptive methods in the United States — used by nearly one in four sexually active women at some point during their lives.
Recent studies have revealed a serious risk that Pfizer failed to disclose for decades: women who use Depo-Provera for more than one year face a significantly increased risk of developing meningiomas — tumors that form in the protective membranes surrounding the brain and spinal cord.
A landmark 2024 study published in The British Medical Journal found that women who used Depo-Provera for longer than one year had a 5.5 times greater risk of developing an intracranial meningioma requiring surgery. A second study published in 2025 in JAMA Neurology by Cleveland Clinic researchers confirmed these findings in a U.S. population of more than 10 million women.
Despite this growing body of evidence — and despite the fact that other countries had already added meningioma warnings to the drug's label — Pfizer did not update the U.S. warning label until the FDA required it in December 2025. By that time, millions of women had used the drug without being informed of the risk.
Price Armstrong, LLC is a US News Best Law Firm that represents individuals harmed by dangerous drugs and medical devices. Our attorneys have recovered hundreds of millions of dollars for clients nationwide. If you or a loved one developed a meningioma after using Depo-Provera, contact us today for a free case evaluation.
What Is the Status of the Depo-Provera Lawsuit?
Lawsuits are being filed now, and you may be able to participate and recover monetary damages.
Depo-Provera meningioma lawsuits have been consolidated into a federal multidistrict litigation (MDL 3140) in the U.S. District Court for the Northern District of Florida, before the Honorable M. Casey Rodgers. As of April 2026, more than 3,400 cases are pending in the MDL, with the number growing rapidly each month.
The FDA approved a new meningioma warning on the Depo-Provera label in December 2025 — a development that has significantly strengthened claims against Pfizer. The first bellwether trial is scheduled for December 2026.
This is not a class action. Each person who has been harmed must file their own individual lawsuit to participate in any recovery. New cases are still being accepted.
What Is Depo-Provera and Why Is It Linked to Brain Tumors?
Depo-Provera (medroxyprogesterone acetate) is a hormonal birth control injection given every three months. It works by preventing ovulation, thickening cervical mucus, and thinning the uterine lining. In addition to contraception, doctors have prescribed it to manage conditions such as endometriosis and abnormal uterine bleeding.
The drug delivers a 150 mg dose of synthetic progestin via intramuscular injection — a high dose that remains active in the body for months at a time. Researchers have identified that this prolonged hormonal exposure may promote the growth of meningiomas, which are hormone-sensitive tumors.
What Is a Meningioma?
A meningioma is a tumor that develops in the meninges — the protective membranes that surround the brain and spinal cord. While most meningiomas are classified as non-cancerous, they can grow large enough to compress brain tissue, nerves, and blood vessels, leading to serious neurological symptoms and, in many cases, requiring brain surgery to remove.
Meningiomas often grow slowly and may go undetected for years. Many women do not connect their symptoms to Depo-Provera use until long after the damage has been done.
Products Covered by This Litigation:
- Depo-Provera CI (150 mg intramuscular injection)
- Depo-SubQ Provera 104 (104 mg subcutaneous injection)
- Authorized generic versions of medroxyprogesterone acetate
What Are the Symptoms and Injuries Linked to Depo-Provera Meningiomas?
Women who developed meningiomas after prolonged Depo-Provera use report a range of serious symptoms and health consequences, including:
- Chronic headaches — persistent, worsening headaches that do not respond to typical treatment
- Vision changes — blurred vision, double vision, or partial vision loss
- Hearing loss — partial or complete loss of hearing, sometimes in one ear
- Seizures — new-onset seizure activity caused by tumor pressure on the brain
- Cognitive difficulties — memory problems, difficulty concentrating, confusion
- Dizziness and vertigo — balance problems and a persistent sense of disorientation
- Numbness or weakness — loss of sensation or motor function in the arms or legs
- Speech difficulties — slurred speech or difficulty finding words
Consequences reported in lawsuits include:
- Emergency or planned brain surgery (craniotomy) to remove the tumor
- Recurring tumors requiring multiple surgeries over time
- Permanent neurological damage from surgery or tumor growth
- Ongoing medical monitoring and treatment
- Lost wages and diminished earning capacity
- Significant pain, suffering, and reduced quality of life
If you experienced any of these symptoms or outcomes after using Depo-Provera for one year or longer, you may qualify to file a lawsuit.
Meet Amy Rixey — Depo-Provera Case Lead, Director of Client Relations
Amy brings nearly two decades of experience in Mass Torts, Product Liability, and complex litigation. Before joining Price Armstrong, she worked in the Orthopedics Department at UAB Hospital — giving her a direct understanding of how medical systems work and what patients face when a drug they trusted causes serious harm.
Amy holds a B.S. from the University of Alabama Honors College and a Post-Baccalaureate degree in Nuclear Medicine and Medical Imaging. That combination of medical and legal experience is rare, and it's why she leads client relationships across our most complex case types.
She understands that women who are dealing with a brain tumor diagnosis after years of trusting their birth control are facing something no one should have to go through alone. Her job is to make sure every client feels heard, informed, and supported throughout the entire process.
If you or a loved one were diagnosed with a meningioma after using Depo-Provera, Amy is who you'll speak with after your initial case review.
Our Commitment to You
- You may qualify for a lawsuit at no cost
- You don't pay unless we win your case
- We assist clients across all 50 states
Amy Rixey
Depo-Provera Case Lead
Director of Client Relations
Nicholas Armstrong
Attorney
How Do I Join the Depo-Provera Lawsuit?
Contact us through the form below, the chat button on this page, or call us directly at +1 888 670 9542. All legal claims may be subject to time limits, and this litigation is moving quickly. A free, confidential case evaluation is the first step.
Contact usFrequently Asked Questions
You may qualify if you received Depo-Provera, Depo-SubQ Provera 104, or an authorized generic version for one year or longer and were subsequently diagnosed with an intracranial meningioma. Even if you stopped using Depo-Provera years ago, you may still have a case. We will be able to make an initial determination through a confidential, free discussion with our attorneys and paralegals.
No, the Depo-Provera litigation is not a class action. It is consolidated as an MDL (multidistrict litigation), which means all federal cases are coordinated before a single judge for efficiency. The key difference is that in an MDL, every person who has been harmed must file their own individual lawsuit to receive any recovery.
Our firm operates solely on a contingency fee agreement. That means we advance all costs and our time, and we only receive a fee if we are successful in obtaining compensation for you. There are absolutely no out-of-pocket costs for you to join the case and seek the relief you deserve.
Women who developed meningiomas after prolonged Depo-Provera use may be able to recover compensation for medical expenses (past and future), lost wages and earning capacity, pain and suffering, emotional distress, and diminished quality of life. The amount depends on the severity of the diagnosis, the treatment required, and the long-term impact on your health and daily life.
Yes. Many women who are now being diagnosed with meningiomas stopped receiving injections years or even decades ago. Meningiomas are slow-growing tumors that may not cause noticeable symptoms until long after exposure. However, statutes of limitations do apply and vary by state, so it is important to contact an attorney as soon as possible to protect your rights.
As of April 2026, more than 3,400 Depo-Provera lawsuits are pending in MDL 3140 in the Northern District of Florida before Judge M. Casey Rodgers. The FDA added a meningioma warning to the Depo-Provera label in December 2025. Expert depositions on general causation are underway, and the first bellwether trial is scheduled for December 2026.
